Since GTA 4 rebooted the continuity we haven't officially had a game set in Vice City (Miami) in the current continuity. My money is on them doing that for the next game honestly. Gotta agree with Juan that a game set in Japan could be cool as hell though. I also really hope the female protagonist rumors are true. A Vice City game could actually fit that well too. Some drug baroness who gets back-stabbed by a trusted underling or something could be really cool.
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